Status:
UNKNOWN
Atelectasis Formation: Role of Positive Pressure Breathing, Hyperoxia, and Hypobaria
Lead Sponsor:
Direction Centrale du Service de Santé des Armées
Collaborating Sponsors:
Uppsala University Hospital
Percy Hospital
Conditions:
Pulmonary Atelectasis
Eligibility:
MALE
25-45 years
Phase:
NA
Brief Summary
The primary aim of this project is to get further knowledge of the physiology of flight atelectasis and its prevention. We seek to: 1) assess whether low levels of positive pressure breathing can prev...
Detailed Description
The effect of positive pressure breathing on lung function is being studied, when applied during exposure to hyperoxia and +Gz-accelerations. Focus is on lung tissue compression, ventilation and regio...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- normal lung function checked by pulmonary function tests.
- normal ECG
- normal clinical examination
- Aim 1 exclusion criteria:
- smoking
- myopia
- past medical history of heart or lung disease
- current medical treatment for heart or lung disease
- past medical history of back pain or spine trauma or disease
- otitis
- bad tolerance to +Gz accelerations (G-induced loss of consciousness, motion sickness)
- claustrophobia in the centrifuge gondola
- Aim 2 exclusion criteria:
- smoking
- past medical history of heart or lung disease
- current medical treatment for heart or lung disease
- otitis
- bad tolerance to the altitude chamber (15,000 ft): ear pain, claustrophobia
Exclusion
Key Trial Info
Start Date :
September 14 2015
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2020
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03311347
Start Date
September 14 2015
End Date
January 1 2020
Last Update
May 14 2019
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Armed Forces Biomedical Research Institute
Brétigny-sur-Orge, France, 91 223
2
Department of Radiology, Percy hospital
Clamart, France, 92140