Status:
RECRUITING
Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study
Lead Sponsor:
Indiana University
Conditions:
Eosinophilic Esophagitis
Eligibility:
All Genders
18-65 years
Brief Summary
This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus. Furthermore, previous studies of the esoph...
Eligibility Criteria
Inclusion
- 1\. Presence of eosinophilia on esophageal biopsy, defined as a peak count of \> 15 eosinophils per high power field (HPF) on light microscopy based on biopsies from at least 2 of the 3 biopsy segments (upper, middle and distal esophagus)
Exclusion
- Secondary causes of esophageal eosinophilia has been excluded, such as eosinophilic GI diseases, celiac disease, Crohn's disease, esophageal infection, hypereosinophilic syndrome, drug hypersensitivity, vasculitis, pemphigus, connective tissue diseases, graft vs. host disease
- Age \< 18 or \> 65 years
- Contraindication for biopsy, such as presence of esophageal varices, coagulopathy
- History of esophageal surgery, gastric or esophageal malignancy, anatomical abnormality, or major primary motility disorder (such as achalasia)
- Pregnancy
- Prisoners
Key Trial Info
Start Date :
November 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03312686
Start Date
November 1 2016
End Date
December 31 2026
Last Update
November 24 2025
Active Locations (2)
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1
Indiana University Health University Hospital
Indianapolis, Indiana, United States, 46202
2
Indiana University
Indianapolis, Indiana, United States, 46202