Status:
COMPLETED
The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial
Lead Sponsor:
Arizona State University
Collaborating Sponsors:
University of Rochester
Mayo Clinic
Conditions:
Mild Cognitive Impairment
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
This multi-site clinical trial occurs at the University of Minnesota and University of Rochester. It tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevan...
Detailed Description
Because almost all drug trials for Alzheimer's disease (AD) have failed, developing non-pharmacological interventions with strong potential to prevent or delay the onset of AD in high-risk populations...
Eligibility Criteria
Inclusion
- A clinical diagnosis of MCI
- Community-dwelling
- Age 65 years and older
- English-speaking
- Adequate visual acuity
- Verified exercise safety by medical provider
- Stable on drugs affecting cognitive and psychological status
- Verified MRI safety
- Capacity to consent
Exclusion
- Geriatric Depression Scale \< 5
- Resting heart rate (HR) ≤50 due to arrhythmia or ≥100 beats/min
- Neurological (e.g., dementia, head trauma), psychiatric (e.g., bipolar, schizophrenia, or depression), or substance dependency (alcohol or chemical dependency) in the past 5 years that are the main contributor to MCI
- Contraindications to exercise, e.g. unstable angina, recent surgery
- New symptoms or diseases that have not been evaluated by a health care provider
- Current enrollment in another intervention study related to cognitive improvement (reduce confounding effects on outcomes)
- Abnormal MRI findings
Key Trial Info
Start Date :
July 5 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 17 2024
Estimated Enrollment :
146 Patients enrolled
Trial Details
Trial ID
NCT03313895
Start Date
July 5 2018
End Date
July 17 2024
Last Update
April 25 2025
Active Locations (4)
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1
Arizona State University
Phoenix, Arizona, United States, 85004
2
Stanford University
Stanford, California, United States, 94305
3
University of Minnesota
Minneapolis, Minnesota, United States, 55455
4
University of Rochester
Rochester, New York, United States, 14642