Status:
UNKNOWN
Prophylactic Alpha-blockers in the Prevention of Urinary Retention Post Inguinal Hernia Repair
Lead Sponsor:
National University Hospital, Singapore
Collaborating Sponsors:
National University of Singapore
Conditions:
Urinary Retention
Inguinal Hernia
Eligibility:
MALE
41-80 years
Phase:
EARLY_PHASE1
Brief Summary
Post operative urinary retention ( POUR) is caused by sympathetic activation of the internal urethral sphincter after surgery. The smooth muscles of the around the internal urethral sphincter have bee...
Detailed Description
The study will be conducted as a randomised, double blind, placebo-controlled trial. This is a single center trial. The experimental design and procedure will be performed in accordance to the CONSORT...
Eligibility Criteria
Inclusion
- Males of 41 to 80 years old who are going for elective inguinal hernia repair (laparoscopic or open) under general anesthesia.
Exclusion
- Patient whom has any of the following will be excluded:
- Contraindication to tamsulosin : known allergy, known orthostatic hypotension, significant cardiac co-morbidities ( New york heart association functional classification \>2) or heart failure
- End stage renal failure
- More than two anti-hypertensive use/long term alpha blockers/beta blockers/anticholinergic (eg : buscopan)
- Previous urological or pelvic surgery
- Known benign prostatic hyperplasia on medications
- Long term indwelling catheters
- Concurrent neurologic disease such as stroke, poliomyelitis, cerebral palsy, multiple sclerosis, spinal lesions, diabetic and alcoholic neuropathy
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2019
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT03314259
Start Date
December 1 2017
End Date
June 1 2019
Last Update
October 19 2017
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