Status:
COMPLETED
Duality of Lipids: the Athlete's Paradox
Lead Sponsor:
German Diabetes Center
Collaborating Sponsors:
Maastricht University
Conditions:
Insulin Resistance, Diabetes
Lipid Metabolism Disorders
Eligibility:
All Genders
18-69 years
Phase:
NA
Brief Summary
Accumulation of intramyocellular lipids (IMCLs) due to increased supply of fatty acids can induce defects in the insulin signaling cascade, causing skeletal muscle insulin resistance. However, the cau...
Detailed Description
Type 2 diabetes (T2D) is characterized by an increasing insensitivity of muscle, fat and liver cells to the hormone insulin. About 9% of the global population is affected by this condition and mortali...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Insulin-resistant, non-athletic persons with a comparable content of IMCLs as the athletes
- Healthy, insulin-sensitive, normal-weight, non-athletic (BMI 18-25 kg / m2) individuals
- Endurance trained individuals (VO2max≥60 mL / kg / min ♂ and 45 mL / kg / min ♀)
- Male and female, age between ≥ 18 and ≤ 69 years
- Exclusion criteria
- Acute infections / fever
- Immunosuppressive therapy
- Serious heart, kidney or liver disease: - New York Heart Association-Classification (NYHA) stage ≥ II - creatinine ≥ 1.6 mg / dl - Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) ≥ two-fold upper reference value - severe peripheral artery disease (PAD) (stage IV)
- autoimmune diseases
- Anemia (Hb \<12g / l)
- Severe psychiatric illness or addiction
- Malignant cancer
- Participation in another intervention study
- Blood clotting disorders or increased risk of thrombosis
- Pregnancy, lactation
- Cigarettes (or non-smokers \<1 year)
- alcohol consumption (men\> 30g / d, women\> 20g / d)
- ECG changes (ST reductions or - elevations, high-grade rhythm disorders (salvage or polytope extrasystoles, ventricular tachycardia)
- Heart diseases (angina pectoris at rest or under light load, myocardial infarction, thromboembolic processes / pulmonary embolism or severe arteriosclerosis, acute myocarditis or pericarditis, cardiac wall aneurysms, cor pulmonale, aortic stenosis)
- Hypertension (\> 220/120 mmHg)
- Pacemaker
- Metallic and magnetic implants (for example, mechanical heart valves, joint prostheses, clip after vascular surgery, middle and inner ear implants or fresh dental implants, penis implants)
- Waist circumference\> 135cm
- Claustrophobia
Exclusion
Key Trial Info
Start Date :
April 3 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03314714
Start Date
April 3 2017
End Date
June 1 2023
Last Update
June 13 2023
Active Locations (2)
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1
German Diabetes Center
Düsseldorf, North Rhine-Westphalia, Germany, 40225
2
Maastricht University
Maastricht, Netherlands, 6200