Status:
UNKNOWN
Initial Hemopurification Strategy for Acute Paraquat Poisoning in Adults
Lead Sponsor:
Peking Union Medical College Hospital
Collaborating Sponsors:
The First Affiliated Hospital of Zhengzhou University
National Natural Science Foundation of China
Conditions:
Poisoning
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
HeSAPP is a single-center, non-blinded, parallel-group randomized controlled trial studying the hemopurification strategy for acute paraquat(PQ) poisoned patients. The intervention to be investigated ...
Detailed Description
Patients diagnosed with acute paraquat poisoning in the Emergency Room of the First Affiliated Hospital of Zhengzhou University would be stratified according to their urine dithionite test results and...
Eligibility Criteria
Inclusion
- Suspected paraquat ingestion history (intended or accidental), which is confirmed by positive urine dithionite result (light blue, navy blue and dark blue).
- Arriving at the ER within 24 hours after PQ digestion.
- No known current pregnancy or lactation.
- Absence of cardiac arrest after poisoning, and no previous or present history of chronic kidney disease, chronic liver disease, respiratory failure, COPD, asthma, heart failure, pancreatic disease, acute coronary syndrome (ACS) or stoke.
- No known combined ingestion with other poisons or alcohol.
- No previous blood purification treatment prior to admission.
- No known participation in other medical trials.
- Agreement on informed consent.
Exclusion
- Patients who are unable to comply with the procedures of the present trial, including those who change therapy or withdraw treatment.
- Patients who develop severe allergic response to HP materials.
- Patients who do not receive intervention within 4 hours after admission in reality.
Key Trial Info
Start Date :
October 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2022
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT03314909
Start Date
October 1 2018
End Date
February 28 2022
Last Update
April 17 2018
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