Status:
COMPLETED
Absorption & Elimination of Radiolabelled GSK2269557
Lead Sponsor:
GlaxoSmithKline
Conditions:
Pulmonary Disease, Chronic Obstructive
Eligibility:
MALE
30-55 years
Phase:
PHASE1
Brief Summary
GSK2269557 is being developed as an anti-inflammatory agent for the treatment of chronic obstructive pulmonary disease (COPD) and other inflammatory lung diseases such as asthma. This study is designe...
Eligibility Criteria
Inclusion
- Subject must be 30 to 55 years of age inclusive, at the time of signing the informed consent.
- Subjects who are overtly healthy as determined by the investigator or medically qualified designee based on a medical evaluation including medical history, physical examination, vital signs, laboratory tests, and cardiac monitoring; A subject with a clinical abnormality or laboratory parameter(s) which is/are not specifically listed in the inclusion or exclusion criteria, outside the reference range for the population being studied may be included only if the investigator agrees and documents that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures.
- A history of regular bowel movements (averaging one or more bowel movements per day).
- Body weight \>= 50 kilograms (Kg) and body mass index (BMI) within the range 19.0-31.0 kg per meter square (kg/m\^2) (inclusive).
- Male subjects will be included.
- Subjects with female partners of childbearing potential must agree to use contraception during the treatment period, from the time of first dose of study medication until follow-up, and refrain from donating sperm during this period.
- Capable of giving signed informed consent.
Exclusion
- Alanine aminotransferase (ALT) \> 1.5x Upper limit of normal (ULN).
- Bilirubin \> 1.5xULN (isolated bilirubin \> 1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \< 35%).
- Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
- Mean QT duration corrected for heart rate by Fridericia's formula (QTCF) \> 450 milliseconds (msec).
- Any clinically relevant abnormality identified at the screening medical assessment (physical examination/medical history), clinical laboratory tests, or 12-lead ECG.
- A pre-existing condition(s) interfering with normal gastrointestinal (GI) anatomy or motility, including constipation, malabsorption or other GI dysfunction which may interfere with the absorption, distribution, metabolism or elimination of the study drug. Subjects with a history of cholecystectomy must be excluded.
- At screening, a supine or semi-supine BP that is persistently higher (triplicate measurements at least 2 minutes apart than 140/90 millimeters of mercury (mmHg).
- At screening, a supine or semi-supine mean heart rate (HR) outside the range 40-90 beats per minute (BPM).
- Subject is mentally or legally incapacitated.
- A history of respiratory disease (example given \[e.g.\] history of asthma) in the last 10 years.
- Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) before the first dose of study medication, unless in the opinion of the investigator and GlaxoSmithKline (GSK) Medical Monitor the medication will not interfere with the study procedures or compromise subject safety.
- Need of Paracetamol or Acetaminophen, at doses of \> 2 grams (g)/day. Other concomitant medication may be considered on a case by case basis by the GSK Medical Monitor.
- The subject has participated in a clinical trial and has received an investigational product (IP) within 3 months before their first dose in the current study.
- Participation in a clinical trial involving administration of 14C-labelled compound(s) within the last 12 months. A subject's previous effective dose will be reviewed by the medical investigator to ensure there is no risk of contamination/carryover into the current study.
- Presence of hepatitis B surface antigen (HBsAg), or positive hepatitis C antibody test result at screening.
- Positive Hepatitis C ribonucleic acid (RNA) test result at screening or within 3 months prior to first dose of study treatment.
- A positive test for Human Immunodeficiency Virus (HIV) antibody.
- A positive pre-study drug/alcohol screen.
- Exposure to more than four new chemical entities within 12 months before the subject's first dose.
- Subjects have received a total body radiation dose of greater than 5.0 micro sievert (mSv) (upper limit of World Health Organization \[WHO\] category II) or exposure to significant radiation (e.g. serial x-ray or computed tomography \[CT\] scans, barium meal etc) in the 12 months before this study.
- An occupation which requires monitoring for radiation exposure, nuclear medicine procedures or excessive x-rays within the past 12 months.
- Participation in the study would result in donation of blood or blood products in excess of 500 milliliters (mL) within a 90 day period.
- Unwillingness or known inability to follow the procedures outlined in the protocol, including the use of the Enterotest capsule.
- History of regular alcohol consumption within 6 months of the study, defined as an average weekly intake of \>21 units. One unit is equivalent to 8 g of alcohol: a halfpint (approximately 240 mL) of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits.
- Urinary cotinine levels indicative of smoking; current smoker; or ex-smokers who gave up less than 6 months ago or who have a history of more than 10 pack-years. Pack-years = cigarettes per day x number of years smoked/20
Key Trial Info
Start Date :
November 14 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 22 2017
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT03315559
Start Date
November 14 2017
End Date
December 22 2017
Last Update
March 13 2020
Active Locations (1)
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1
GSK Investigational Site
London, United Kingdom, NW10 7EW