Status:
COMPLETED
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins
Lead Sponsor:
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Conditions:
Acute Lung Injury
Eligibility:
All Genders
18-60 years
Brief Summary
As novel agonists of Wnt/β-catenin signaling pathway, R-spondin proteins constitute a class of ligands, including R-spondin 1/2/3/4, functioning through their receptors leucine-rich repeat-containing ...
Detailed Description
Mechanical ventilation is a critical intervention for patients with acute respiratory failure. However, lung overdistension induced by mechanical ventilation also causes pulmonary endothelial dysfunct...
Eligibility Criteria
Inclusion
- undergo elective surgery with mechanical ventilation lasting for \> 3 hours; classified as physical status I to III according to the American Society of Anesthesiologists Physical Status Classification System; Written informed consent is approved.
Exclusion
- chronic lung disease; recent lung infection; recent anaesthetics or mechanical ventilation treatment; hemodilution with massive fluid supply during surgery; children；women during pregnancy or lactation; being involved in other clinical subjects
Key Trial Info
Start Date :
September 22 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 31 2017
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT03315702
Start Date
September 22 2017
End Date
October 31 2017
Last Update
July 25 2019
Active Locations (1)
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1
Department of Anesthesia, Shanghai Xinhua hospital
Shanghai, Shanghai Municipality, China, 200082