Status:
COMPLETED
Cognitive Training for PTSD
Lead Sponsor:
VA Office of Research and Development
Conditions:
Posttraumatic Stress Disorder
Eligibility:
All Genders
21-55 years
Phase:
NA
Brief Summary
Posttraumatic stress disorder (PTSD) is a chronic, disabling condition that occurs in a subgroup of individuals after experiencing traumatic stress, and is common in Veterans seeking mental health tre...
Detailed Description
Posttraumatic Stress Disorder (PTSD) is one of the most prevalent service-related mental health conditions in treatment-seeking Veterans, yet even gold standard interventions are not universally effec...
Eligibility Criteria
Inclusion
- Eligible participants will be Veterans who:
- meet primary, current DSM-5 criteria for Posttraumatic Stress Disorder
- are literate in English
- intend to remain in the San Diego geographical area for the duration of the study
- are willing to attend assessment and treatment sessions
Exclusion
- for the MRI portion, inability to safely complete fMRI session - unsafe metal in body, e.g.:
- devices such as pacemakers
- metal fragments in the skin like shrapnel
- history of metal work or welding
- history of eye surgery or washes because of metal
- aortic/aneurysm clips
- prosthesis
- bypass surgery/coronary artery clips
- hearing aids
- heart-valve replacement
- intrauterine devices with metal
- shunts
- electrodes
- metal plates/pins/screws
- neuro or bio-stimulators
- older tattoos with metal ink
- piercings the subject is unable or unwilling to remove
- uncorrectable vision problems
- claustrophobia
- inability to lie still on the back for approximately one hour
- inability to safely fit within the dimensions of the fMRI machine
- prior neurosurgery
- pregnancy or current breastfeeding (within 3 months)
- current IV drug use due to potential cerebrovascular effects
- or any other conditions that are deemed by Keck Imaging Center staff to contraindicated to safely complete the fMRI scanning
- a lifetime history of psychotic disorders
- lifetime history of bipolar disorder
- severe substance use disorder within the last year
- other psychiatric conditions that may adversely impact cognition and/or are deemed to require other primary psychological intervention
- history of any neurological disorder that might be associated with cognitive dysfunction, e.g.:
- cerebrovascular accident
- intracranial surgery
- aneurysm
- seizure disorder
- acute suicidality (defined as intent, plan, and/or attempt for severe self-harm within the past 3 months)
- or current circumstances that present a direct threat to the individual and require more imminent intervention, e.g.:
- current domestic abuse
- individuals planning to begin medication changes within the time-frame of the study
- individuals currently undergoing evidence-based psychotherapy for PTSD
- individuals planning non-PTSD related psychosocial therapy change within the pre- to post-treatment time frame of the study
- those with life-threatening or acutely unstable medical conditions
Key Trial Info
Start Date :
June 13 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2023
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT03316196
Start Date
June 13 2018
End Date
May 31 2023
Last Update
September 19 2024
Active Locations (1)
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1
VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States, 92161-0002