Status:
COMPLETED
Effect of Sodium Nitroprusside on Cerebral Blood Flow
Lead Sponsor:
Rigshospitalet, Denmark
Conditions:
Healthy Male Subjects
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
The brain has a high energy demand and requires continuous blood flow. The blood flow to the brain appears to be unaffected by small changes in blood pressure, but brain blood flow may be reduced by a...
Detailed Description
Background Cerebral autoregulation is generally considered to maintain cerebral blood flow (CBF) if mean arterial pressure (MAP) is between 60 and 150 mmHg. Yet, it is controversial whether there is a...
Eligibility Criteria
Inclusion
- Informed consent
- Male
- Age 18-35 years
Exclusion
- Alcohol intake ≥ 420 g / week
- Body mass index below 18 kg/m\^2 and above 25 kg/m\^2
- Smoking
- Beard on the neck
- Chronic cardiac, lung, liver, kidney or metabolic disease that require medication
- Vitamin B12 deficiency
- Anemia
- Leber's hereditary optic neuropathy
- Tobacco-alcohol amblyopia
- Stenosis that obstructs ≥ 16% of the internal carotid artery
- Intake of sildenafil or vardenafil for 24 hours and tadalafil for 48 timer prior to the experiment
- Intake of monoamine oxidase inhibitors
- Neurologic disease considered to affect cerebral blood flow, including epilepsy and multiple sclerosis
Key Trial Info
Start Date :
November 3 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 4 2017
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03317652
Start Date
November 3 2017
End Date
December 4 2017
Last Update
December 8 2017
Active Locations (1)
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1
Department of Anesthesia, Rigshospitalet 2043
Copenhagen, Denmark, DK-2100