Status:
COMPLETED
Role of the Serotonin 5-HT2A Receptor in LSD-induced Altered States of Consciousness (LDR-Study)
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Healthy
Eligibility:
All Genders
25-65 years
Phase:
EARLY_PHASE1
Brief Summary
Serotonin receptors, especially the 5HT2A receptor, are thought to be involved in the effects of various recreationally used psychedelic substances such as LSD. LSD potently stimulates the 5-HT2A rece...
Eligibility Criteria
Inclusion
- Age between 25 and 65 years.
- Understanding of the German language.
- Understanding the procedures and the risks associated with the study.
- Participants must be willing to adhere to the protocol and sign the consent form.
- Participants must be willing to refrain from taking illicit psychoactive substances during the study.
- Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day.
- Participants must be willing not to drive a traffic vehicle or to operate machines within 48 h after substance administration.
- Women of childbearing potential must have a negative pregnancy test at the beginning of the study. Pregnancy tests are repeated before each study session.
- Women of childbearing potential must be willing to use double-barrier birth control
- Body mass index 18-29 kg/m2.
Exclusion
- Chronic or acute medical condition
- Current or previous major psychiatric disorder
- Psychotic disorder in first-degree relatives
- Illicit substance use (with the exception of cannabis) more than 10 times or any time within the previous two months.
- Pregnant or nursing women.
- Participation in another clinical trial (currently or within the last 30 days)
- Use of medications that may interfere with the effects of the study medications (any psychiatric medications)
- Tobacco smoking (\>10 cigarettes/day)
- Consumption of alcoholic drinks (\>10/week)
Key Trial Info
Start Date :
November 28 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 11 2019
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03321136
Start Date
November 28 2017
End Date
July 11 2019
Last Update
August 28 2019
Active Locations (1)
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1
University Hospital
Basel, Switzerland, 4031