Status:
COMPLETED
Colonic Propionate, Appetite, and Weight Loss
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
University of Glasgow
Conditions:
Healthy Obesity, Metabolically
Appetite Regulation
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The current protocol aims to investigate the impact of the propionate ester in conjugation with restricted diet on appetite and weight loss.
Detailed Description
DIET AND OBESITY: Obesity has reached epidemic proportions worldwide. In the United Kingdom, 58% of adult women and 65% of adult men are either overweight or obese (Health and Social Care Information...
Eligibility Criteria
Inclusion
- overweight or obese ((BMI) of 25-35 kg/m2)
- healthy
- aged between 18 and 65 years
Exclusion
- Weight change of ≥ 3kg in the preceding 2 months
- Undergone any weight loss surgery or gastric procedures to promote weight loss
- Current smokers
- Substance abuse
- Excess alcohol intake
- Pregnancy
- Diabetes
- Cardiovascular disease
- Cancer
- Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome
- Kidney disease
- Liver disease
- Pancreatitis
- Use of medications likely to interfere with energy metabolism, appetite regulation and hormonal balance, including: anti-inflammatory drugs or steroids, antibiotics, androgens, phenytoin, erythromycin or thyroid hormones.
- Any participants with the above conditions would already have an altered pattern of hormones and inflammatory molecules because of their disease process and would therefore give us confounding or misleading results.
Key Trial Info
Start Date :
March 29 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 11 2017
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03322514
Start Date
March 29 2017
End Date
November 11 2017
Last Update
November 20 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
NIHR/Wellcome Trust Imperial Clinicial Research Facility
London, United Kingdom, W12 0NN