Status:
COMPLETED
FCH PET/MRI Parathyroid Localization
Lead Sponsor:
University Health Network, Toronto
Conditions:
18F-fluorocholine
Positron-Emission Tomography
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A prospective trial comparing the accuracy of \[F-18\]-FCH PET/MRI to US and 99mTc-MIBI SPECT/CT for pre-operative parathyroid localization in patients with primary hyperparathyroidism
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Biochemically proven primary hyperparathyroidism
- Indication for parathyroidectomy as per institutional guidelines
Exclusion
- Contraindication for MRI as per current institutional guidelines.
- Contraindication for Gadolinium injection as per current institutional guidelines.
- Renal failure
- Inability to lie supine for at least 45 minutes.
- Any participant who is pregnant or breastfeeding.
- Participants receiving erythropoietin (i.e. for hemochromatosis; might lead to false negative results due to stimulation of bone marrow metabolism)
- Familial HPT syndromes
- Participant currently being treated with any cytotoxic chemotherapy
Key Trial Info
Start Date :
April 3 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 23 2021
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT03324893
Start Date
April 3 2018
End Date
June 23 2021
Last Update
December 7 2023
Active Locations (1)
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1
UHN
Toronto, Ontario, Canada, m5g 2c4