Status:
ACTIVE_NOT_RECRUITING
Immunogenicity of Alternative Annual Influenza Vaccination Strategies in Older Adults in Hong Kong
Lead Sponsor:
The University of Hong Kong
Collaborating Sponsors:
Centers for Disease Control and Prevention
Conditions:
Influenza, Human
Eligibility:
All Genders
65-82 years
Phase:
PHASE4
Brief Summary
This study allows to evaluate the strength and duration of immune responses between annual receipt of standard inactivated vaccine and alternative potent vaccines, including annual receipt of adjuvant...
Detailed Description
Background: The typical vaccination strategy of annual administration with inactivated trivalent influenza vaccine (TIV) or quadrivalent influenza vaccine (QIV) may provide suboptimal protection to ol...
Eligibility Criteria
Inclusion
- • Adult aged 65-82 years attending ECC and EDC who has not received 2017/18 seasonal influenza vaccine and is willing to receive annual influenza vaccination
Exclusion
- Individuals who show signs of dementia (do not pass the Mini-cog test under Appendix 1a: Recruitment Screening Log) or significant cognitive impairment and are not competent to give their consent.
- Individuals who report medical conditions not suitable to receive inactivated influenza vaccines, such as:
- Severe allergic reaction (e.g., anaphylaxis) after previous dose of any influenza vaccine; or to a vaccine component, including egg protein;
- Moderate or severe acute illness with or without fever after any previous influenza vaccination; or
- A history of Guillain-Barré syndrome (GBS) within 6 weeks of previous influenza vaccination.
- Individuals, who report medical conditions not suitable to receive intramuscular injection, such as:
- bleeding disorders
- habitually taking anticoagulants (with the exception of antiplatelets such as aspirin).
- Individuals who have any medical conditions not suitable to receive inactivated influenza vaccines as determined by a clinician.
Key Trial Info
Start Date :
October 7 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2026
Estimated Enrollment :
1861 Patients enrolled
Trial Details
Trial ID
NCT03330132
Start Date
October 7 2017
End Date
December 1 2026
Last Update
December 11 2023
Active Locations (1)
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1
The University of Hong Kong
Hong Kong, China