Status:
ACTIVE_NOT_RECRUITING
A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia
Lead Sponsor:
Seattle Children's Hospital
Conditions:
Leukemia
Lymphoma
Eligibility:
All Genders
Up to 30 years
Phase:
PHASE1
Brief Summary
Patients with relapsed or refractory leukemia often develop resistance to chemotherapy and some patients who relapse following CD19 directed therapy relapse with CD19 negative leukemia. For this reaso...
Eligibility Criteria
Inclusion
- First 2 subjects: male and female subjects age ≥18 and \< 27 years (as of 2/16/18 the first 2 subjects were enrolled and treated); subsequent subjects \<31 years.
- Diagnosis of CD19+22+ leukemia
- Disease status:
- If post allogeneic HCT: Confirmed CD19+CD22+ leukemia recurrence defined as at least 0.01% disease following allogeneic HCT
- If relapse/refractory status with no prior history of allogeneic HCT, one of the following:
- Second or greater marrow relapse, with or without extramedullary disease
- First marrow relapse at end of first month or re-induction with marrow having at least 0.01 % blasts by morphology and/or MPF
- Primary refractory as defined as greater than 5% blasts by multi-parameter flow after at least 2 separate induction regimens.
- Subject has indication for HCT but has been deemed ineligible, inclusive of persistent MRD prior to HCT
- Asymptomatic from CNS involvement, if present, and in the opinion of the Principal Investigator with a reasonable expectation that disease burden can be controlled in the interval between enrollment and T-cell infusion. Subjects with significant neurologic deterioration will not be eligible for T-cell infusion until stabilized.
- Free from active GVHD and off immunosuppressive GVHD therapy for 4 weeks prior to enrollment
- Lansky or Karnofsky performance score of at least 50
- Life expectancy of at least 8 weeks
- Recovered from acute toxic effects of all prior chemotherapy, immunotherapy, and radiotherapy
- At least 7 days post last chemotherapy administration (excluding intrathecal maintenance chemotherapy)
- At least 7 das post last systemic corticosteroids administration (unless physiologic replacement dosing)
- No prior genetically modified cell therapy that is still detectable or virotherapy
- Adequate organ function
- Adequate laboratory values
- Willing to participate in long-term follow-up for up to 15 years, if enrolled in the study and receive T cell infusion
- Patients of childbearing/fathering potential must agree to use highly effective contraception from the time of initial T cell infusion through 12 months following the last T cell infusion
Exclusion
- Presence of active clinically significant CNS dysfunction
- Pregnant or breast-feeding
- Unable to tolerate apheresis procedure
- Presence of active malignancy other than CD19+CD22+ leukemia
- Presence of active severe infection
- Presence of any concurrent medical condition that, in the opinion of the Principal Investigator, would prevent the patient from undergoing protocol-specified therapy
Key Trial Info
Start Date :
November 3 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 3 2035
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT03330691
Start Date
November 3 2017
End Date
March 3 2035
Last Update
December 15 2025
Active Locations (5)
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1
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
2
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
3
Riley Hospital for Children
Indianapolis, Indiana, United States, 46202
4
Seattle Children's Hospital
Seattle, Washington, United States, 98105