Status:
COMPLETED
Changes of Soft and Hard Tissues After Alveolar Ridge Preservation: Freeze-dried Bone Allograft vs. L-PRF Clot
Lead Sponsor:
University of Manitoba
Conditions:
Alveolar Bone Loss
Tooth Loss
Eligibility:
All Genders
22+ years
Phase:
PHASE2
PHASE3
Brief Summary
A Clinical Trial to study the effectiveness between two, tooth socket grafting materials namely, Freeze Dried Bone Allograft (human derived bone particles) and Leukocytic-Platelet Rich Fibrin (the pat...
Detailed Description
A prospective,randomized clinical trial will be conducted to determine whether L-PRF, compared to freeze dried bone allograft, will result in comparable volumetric shrinkage of the alveolar ridge and ...
Eligibility Criteria
Inclusion
- Subjects with molars or premolars indicated for extraction.
- Patients that present with a post extraction class I and II socket (\<30% bone loss on the buccal or lingual plate, measured from the most coronal aspect of intact bone to the most apical aspect of the defect divided by the measurement from the most apical aspect of the defect to the apex of the socket x 100).
- Patients presenting with the need for single extractions.
- Patients with general good health that does not have a condition contra-indicating routine dental treatment, extraction and implant placement.
- Patients that are compliant with the research protocol and methods.
- Patients that have read, understood and signed an informed consent form.
Exclusion
- Extraction and ridge preservation indicated for teeth other than premolars and molars.
- Patients that present with a post extraction class III socket (\>30% bone loss on the buccal or lingual plate, measured from the most coronal aspect of intact bone to the most apical aspect of the defect divided by the measurement from the most apical aspect of the defect to the apex of the socket x 100)
- Patients deemed eligible for immediate implant placement following extraction and intra-operative assessment by the attending supervisor.
- Patients that present with an oral-antral communication, post extraction.
- Patients that presents with the need for multiple, side by side extractions.
- Patients with coagulation disorders, on corticosteroids, uncontrolled diabetes mellitus, or any systemic disease where periodontal surgery is contraindicated and healing may be compromised.
- Pregnant and nursing women.
- Patients with any contact hypersensitivity to the related materials used in the study.
- Heavy tobacco users, \>10 cigarettes per day.
- Patients unwilling to sign consent or follow the protocol of the study.
Key Trial Info
Start Date :
January 3 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 2 2019
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT03331185
Start Date
January 3 2018
End Date
April 2 2019
Last Update
April 30 2020
Active Locations (1)
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1
Graduate Periodontic Clinic - University of Manitoba
Winnipeg, Manitoba, Canada, R3E 0W2