Status:
COMPLETED
Closed Eye Neutrophils in Dry Eye Disease
Lead Sponsor:
University of Alabama at Birmingham
Collaborating Sponsors:
Allergan Sales, LLC
Conditions:
Dry Eye
Ocular Inflammation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this prospective study is to evaluate different inflammatory cells that accumulate on the ocular surface, during sleep, and how these cells may contribute to dry eye disease. This study...
Detailed Description
Every night during sleep, there is an influx of white blood cells on to the surface of the eye. These cells likely perform a protective function, but it is also possible that their dysregulation could...
Eligibility Criteria
Inclusion
- able to understand and sign an informed consent and HIPAA privacy document
- greater than 18 years of age at time of informed consent
- able and willing to follow protocol instructions, including performing at-home washes of the ocular surface and subsequent delivery of those samples to campus on a regular basis
- must be willing to have blood drawn
Exclusion
- contact lens wear within past three months
- current consumption of cigarettes or tobacco, including e-cigarettes
- participation in any investigational drug studies within 30 days of informed consent
- pregnancy, by self-report
- active ocular infection or inflammation
- any refractive surgery within the past year
- any present Accutane (Isotretinoin) use
- any medication usage that, in the investigator's opinion, could be expected to interfere with the study, such as current use of topical steroids, Restasis, or Xiidra
- have any uncontrolled systemic disease, that in the investigator's opinion could be expected to interfere with the study, for example, conditions associated with dry eye disease
Key Trial Info
Start Date :
November 8 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 14 2019
Estimated Enrollment :
153 Patients enrolled
Trial Details
Trial ID
NCT03332342
Start Date
November 8 2017
End Date
May 14 2019
Last Update
May 17 2019
Active Locations (1)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294