Status:
COMPLETED
Physical Fitness as Klotho Protein Stimulator.
Lead Sponsor:
Manuel Castillo Garzón
Conditions:
Physical Activity
Aging
Eligibility:
All Genders
40-65 years
Phase:
NA
Brief Summary
FIT-AGING will determine the effect of different exercise modalities on α-Klotho protein (primary outcome) in sedentary healthy adults. FIT-AGING also investigate the physiological consequences of act...
Detailed Description
Aims: The plasma Klotho protein concentration (α-Klotho protein), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-aging therapy against functional decli...
Eligibility Criteria
Inclusion
- Age: 40-65 years
- BMI:18.5-35 kg/m2
- Not engaged in regular physical activity \>20min on \>3days/week
- Not participating in a weight loss programme
- Stable weight over the last 5 months (body weight changes\>5kg)
- Participant must be capable and willing to provide consent, understand exclusion criteria and accept the randomized group assignment
- Normal electrocardiogram
Exclusion
- History of cardiovascular disease
- Diabetes
- Pregnancy or planning to get pregnant during study period
- Beta blockers or benzodiapezins use
- Taking medication for thyroid
- Other significant conditions that are life-threatening or that can interfere with or be aggravated by exercise
- Unwillingness to either complete the study requirements or to be randomized into control or training group
- A first-degree relative with history of cancer
Key Trial Info
Start Date :
June 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 23 2017
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT03334357
Start Date
June 1 2016
End Date
December 23 2017
Last Update
October 12 2018
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