Status:
COMPLETED
Reducing Hemodialysis Induced Recurrent Brain Injury to Improve Patients' Lives
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Patients who receive dialysis for kidney failure suffer severe cognitive impairment. Hemodialysis causes circulatory stress and ischemia, which causes severe brain injury. It has been demonstrated tha...
Detailed Description
Hemodialysis patients suffer severe cognitive impairment: Abnormalities of cognitive impairment (predominately sub-cortical defects in executive decision making) are almost universal in hemodialysis (...
Eligibility Criteria
Inclusion
- Male or Female
- Having hemodialysis treatment at least three times per week
- Must be 18 years old or older.
- Ability to speak and understand English
Exclusion
- Exposure to hemodialysis for less than 90 days prior to recruitment
- Established severe cognitive impairment (Montreal Cognitive Assessment test (MoCA) of less than 18 or with a formal diagnosis of dementia)
- Previous clinical stroke
- Taking drugs to blunt response to RIPC (e.g. ciclosporin, ATP-sensitive potassium channel directed drugs)
- Dialysing using lower limb vascular access
- Pregnancy, breastfeeding, or intending pregnancy
- Unable to give consent or understand written information
Key Trial Info
Start Date :
January 8 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 12 2022
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT03342183
Start Date
January 8 2018
End Date
October 12 2022
Last Update
October 18 2022
Active Locations (1)
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1
London Health Sciences Centre
London, Ontario, Canada, N6A 5W9