Status:
TERMINATED
Multimodal Neuroimaging Analysis After Mild Traumatic Brain Injury
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Mild Traumatic Brain Injury
Eligibility:
MALE
18-30 years
Phase:
NA
Brief Summary
Mild Traumatic Brain Injury (mTBI), including concussion, is a real public health problem. Indeed mTBI might induce long-term brain disorders with increased risk of neurodegenerative diseases and the ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Applicable to all :
- \- Male 18 to 25 years, enrolled in French Social Security.
- Group of mTBI patients:
- \- Diagnosis of mTBI in the last 2 weeks confirmed in emergency department of Bordeaux CHU, using the WHO definition (2004): "head trauma ≤ 24h with Glasgow Coma Scale score of 13-15 and with one or more of the three symptoms following: confusion or disorientation, loss of consciousness for 30 minutes or less, posttraumatic amnesia for less than 24h".
- Group of footballers:
- \- Member of the "CFA" and "U19" teams of "Girondins de Bordeaux".
- Group of controls:
- \- Practicing regular physical activity (excluding combat or contact sports).
- Exclusion Criteria :
- Abnormal neurological examination
- Drug addiction including alcohol Taking drugs targeting the central nervous system History of head trauma, or other notion of central nervous system injury
- History of severe high blood pressure, diabetes, chronic cardiovascular pathology, progressive or debilitating disease
- Subject unable to give informed consent
- Contraindication to MRI: head circumference\> 60 - Claustrophobia - Pacemaker, Implantable Neurostimulation, Implantable Defibrillator - Cochlear Implants - Ocular or cerebral ferromagnetic foreign body
- Refusal to be informed of an abnormality detected during MRI.
Exclusion
Key Trial Info
Start Date :
July 18 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 29 2018
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT03342612
Start Date
July 18 2016
End Date
January 29 2018
Last Update
February 26 2019
Active Locations (1)
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1
University Hospital Bordeaux
Bordeaux, France, 33076