Status:
COMPLETED
Resolution of Organ Injury in Acute Pancreatitis - RESORP
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
Medical Research Council
Conditions:
Pancreatitis, Acute
Eligibility:
All Genders
16+ years
Brief Summary
Acute pancreatitis (AP) is inflammation of the pancreas usually triggered by gallstones or drinking excessive alcohol. 80% of people who have an episode of AP will recover without complications. Howev...
Detailed Description
Acute pancreatitis (AP) is a common and devastating disease with an annual incidence of 22-30 per 100,000 in the UK. The incidence is increasing. AP is most commonly triggered by gallstones or alcohol...
Eligibility Criteria
Inclusion
- All patients treated at Royal Infirmary Edinburgh with a clinical or radiological diagnosis of acute pancreatitis will be recruited where possible.
- For the potential clinical diagnosis of acute pancreatitis an appropriate clinical history based on compatible clinical features, will be required (i.e. abdominal pain, nausea and/or vomiting), supported by the finding of elevated serum amylase greater than 3x the upper limit of the reference range for the laboratory (currently 300 U/L).
- For the radiological diagnosis, if applicable, computerised tomography (CT) and/or ultrasound scan (USS) evidence of acute pancreatitis will be accepted.
Exclusion
- The following exclusion criteria will be adhered to:
- i. Patients under the age of 16 years will be excluded from the present study. ii. Prisoners will be excluded from the present study. iii. Patients lacking the capacity to consent will be excluded but can be included if they regain capacity.
- Additional exclusions will apply only to those patients being considered for the nested cohort study:
- iv. Patients not able to undergo MRI scanning for technical reasons will be excluded (e.g. those with cochlear implants, implanted pacemaker) v. Patients with a known allergy to salbutamol
Key Trial Info
Start Date :
November 27 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 16 2022
Estimated Enrollment :
229 Patients enrolled
Trial Details
Trial ID
NCT03342716
Start Date
November 27 2017
End Date
February 16 2022
Last Update
March 28 2022
Active Locations (1)
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1
Royal Infirmary of Edinburgh
Edinburgh, United Kingdom