Status:
RECRUITING
Multicenter Pheochromocytoma and Paraganglioma Evaluation
Lead Sponsor:
Felix Beuschlein
Collaborating Sponsors:
Technische Universität Dresden
Wuerzburg University Hospital
Conditions:
Pheochromocytoma
Paraganglioma
Eligibility:
All Genders
5+ years
Phase:
NA
Brief Summary
Target population: Patients with (1) newly diagnosed or (2) past history of pheochromocytomas and paragangliomas (PPGL) or (3) carrier of genetic mutations in known PPGL susceptibility genes. Intern...
Detailed Description
The long-term goal of the research planned under this protocol is to reduce morbidity and mortality of patients with PPGLs by improving approaches for management, follow-up and therapy of affected pat...
Eligibility Criteria
Inclusion
- male and female patients (≥ 5 years of age), who fulfill one or more of the following criteria: (i) Patients with a newly diagnosed PPGL. (ii) Patients with a previous history of PPGLs. (iii) Carrier of genetic mutations known to predispose for the development of PPGLs.
- All subjects must have read, understood and signed the informed consent form, before inclusion into the study protocol. Signed parental consent must be obtained for children with suspected PPGLs who are enrolled in the study.
Exclusion
- Patients with impaired mental capacity that precludes informed consent.
- Pregnancy does not constitute criteria for exclusion from the protocol. However, in pregnant women no Clonidine testing, no PET scanning, MIBG scanning or contrast CT will be performed.
- Patients at risk from injury from the MRI magnet due to implantable metal or who suffer from anxiety in enclosed spaces are excluded from MRI.
Key Trial Info
Start Date :
November 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2040
Estimated Enrollment :
1148 Patients enrolled
Trial Details
Trial ID
NCT03344016
Start Date
November 1 2017
End Date
November 1 2040
Last Update
July 9 2020
Active Locations (1)
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1
University Hospital Zurich
Zurich, Switzerland, 8091