Status:
RECRUITING
rTMS Response Trajectories in Depression
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Depression
Eligibility:
All Genders
18-64 years
Phase:
NA
Brief Summary
Notwithstanding the cumulative evidence on the safety and efficacy of transcranial magnetic stimulation in depression care, the non-response rate to transcranial magnetic stimulation (TMS) amongst tre...
Detailed Description
1. Sampling Clinical participants will be recruited from the Transcranial Magnetic Stimulation Day Care Centre of Tai Po Hospital based in the New Territories East Service Cluster under the public sec...
Eligibility Criteria
Inclusion
- right-handed
- meet the Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition (DSM-IV) criteria for major depressive disorder
- at least moderate episode or with a score of \>20 on Montgomery-asberg Depression Rating Scale (MADRS) and \>18 on Hamilton Depression Rating Scale(HDRS) 17-item;
- has failed to respond adequately to at least one full course (\>6 weeks) of antidepressant medication or medication intolerant.
Exclusion
- significant head trauma
- active abuse of alcohol or illegal substances
- current psychotic symptoms
- suicide ideation/recent suicide attempts
- other DSM-IV Axis I and II psychiatric diagnosis
- neurological disorders and contraindications to fMRI (e.g. pace makers, metal implants, pregnancy) or rTMS, or having undergone electroconvulsive therapy in the preceding year.
Key Trial Info
Start Date :
August 4 2015
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT03348761
Start Date
August 4 2015
End Date
December 1 2026
Last Update
February 12 2024
Active Locations (1)
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1
Department of Psychiatry, CUHK
Hong Kong, Hong Kong, 852