Status:
COMPLETED
Cocaine Use Disorder and Cortical Dopamine
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Dependence
Eligibility:
All Genders
18-40 years
Phase:
EARLY_PHASE1
Brief Summary
The goal of this study is to use \[C-11\]FLB 457 and amphetamine (oral, 0.5 mg/kg) to measure cortical dopamine transmission in cocaine dependent individuals and healthy controls
Detailed Description
This study seeks to examine dopamine (DA) transmission in vivo, using positron emission tomography (PET) with \[C-11\]FLB 457, in cortical regions of interest in subjects who have a history of cocaine...
Eligibility Criteria
Inclusion
- Subjects with Cocaine Dependence INCLUSION CRITERIA
- Males or Females 18-40
- Fulfill Diagnostic and Statistical Manual (DSM-IV) Diagnosis for Cocaine Dependence
- Medically Healthy MAJOR EXCLUSIONS
- 1\. Major medical, psychiatric, co-morbid drug \& alcohol use disorders 2. Pregnancy or lactation, 3. Contraindications to MRI 4. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year 5. Family History of a psychotic illness or manic episode in first-degree relatives
- Healthy Subjects INCLUSION CRITERIA
- Males or Females 18-40
- Absence of present or past psychiatric conditions (including alcohol or drug dependence)
- A negative urine drug screen
- Medically Healthy
- MAJOR EXCLUSIONS
- Any medical, psychiatric, co-morbid drug \& alcohol use disorders
- Pregnancy or lactation,
- Contraindications to MRI
- Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year
- Family History of a psychotic illness or manic episode, or drug and alcohol Abuse/Dependence in first-degree relatives
Exclusion
Key Trial Info
Start Date :
June 2 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03349606
Start Date
June 2 2010
End Date
June 1 2020
Last Update
June 4 2020
Active Locations (1)
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1
University of PIttsburgh PET Facility
Pittsburgh, Pennsylvania, United States, 15213