Status:
COMPLETED
Deferred Versus Fresh Embryo Transfers
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Infertility, Female
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
Controlled ovarian stimulation (COS) enhances the efficacy of ART (Assisted reproductive technology) by permitting multiple-oocyte yields, but also alters endometrial receptivity (ER) by an advancemen...
Detailed Description
Controlled ovarian stimulation (COS) enhances the efficacy of ART (Assisted reproductive technology) by permitting multiple-oocyte yields, but also alters endometrial receptivity (ER) by an advancemen...
Eligibility Criteria
Inclusion
- Women \[18 - 40\[years of age (according to date of birth at time of informed consent) who are eligible for ovarian stimulation and ART treatment, including intracytoplasmic sperm injection (ICSI)
- Absence of anatomical abnormalities of the reproductive tract that would interfere with implantation or pregnancy
- Absence of any medical condition in which pregnancy is contraindicated
- Motile, ejaculatory sperm must be available (donated and/or cryopreserved sperm is allowed). Intracytoplasmic sperm injection (ICSI) will be allowed during this trial
- Body mass index 18 to 35 kg/m2, inclusive
- Able to understand the study
- Affiliation with a social security scheme
- Dated and signed inform consent
Exclusion
- Altered ovarian reserve (Day3: FSH \>12 UI/l; AMH\<1,0 ng/ml; AFC\<8)
- History or presence of tumours of the hypothalamus or pituitary gland
- Presence of non isolated uni- or bilateral hydrosalpinx
- Abnormal gynaecological bleeding of undetermined origin
- Contraindication to being pregnant and/or carrying a pregnancy to term
- Known infection with human immunodeficiency virus, active hepatitis B or C virus in the female or male partner
- History or presence of ovarian, uterine or mammary cancer
- Known allergy or hypersensitivity to human gonadotropin preparations or to compounds that are structurally similar to any of the other medications administered during the trial
- Substance abuse that would interfere with trial conduct, as determined by the investigator
- Use of testicular or epididymal sperm
- Pregnant patient, nursing patient
- Participation in another ART clinical trial within the past 30 days
- Women who have risk to develop severe ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation (COS) defined as ≥ 18 follicles measuring 10 - 14 mm on the day of triggering
- Women with less than 3 follicles ≥ 15 mm on the triggering day or the day before the triggering
- Women with premature progesterone elevation during COS ( ≥1.5 ng/ml)
- Women with uterine polyps diagnosed during COS
- Participation with another interventional study involving human subjects
Key Trial Info
Start Date :
September 24 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2022
Estimated Enrollment :
237 Patients enrolled
Trial Details
Trial ID
NCT03349905
Start Date
September 24 2018
End Date
March 31 2022
Last Update
October 25 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hôpital Cochin
Paris, France, 75014