Status:
COMPLETED
Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for Precursor Biomarker for Neurodegeneration
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
REM Sleep Behavior Disorder
Neurodegenerative Diseases
Eligibility:
All Genders
45-65 years
Brief Summary
Background: Previous studies have confirmed that most patients with idiopathic REM sleep behaviour disorder (iRBD) eventually develop neurodegenerative diseases. In addition, REM sleep without atonia...
Detailed Description
In the past two decades, a number of studies have confirmed that most patients with idiopathic RBD will eventually develop neurodegenerative diseases, especially α-synucleinopathies. Previous studies,...
Eligibility Criteria
Inclusion
- No family history of RBD;
- Age- and sex- matched with isolated RSWA subjects
- Absence of dream enactment behaviors;
- A score of RBDQ-HK less than 19;
- Absence of RSWA as measured by v-PSG;
- for those individuals with moderate obstructive sleep apnea (AHI \> 15/hour), effective CPAP treatment should be documented and a second night of V-PSG is required to determine RSWA.
Exclusion
- Presence of dream enactment behaviors by self-report or documented by v-PSG;
- Presence of narcolepsy and other neurological diseases that may give rise to RBD and RWSA;
- Presence of neurodegenerative diseases;
- A total score of the MOCA ≤ 22 and the CDR ≥ 1.
- On medication that potentially increases EMG activity and triggers the symptoms of RBD, such as antidepressants;
- On medication that affects dopamine neural transmission;
- Not capable of giving informed consent for participation of the study.
Key Trial Info
Start Date :
October 30 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 8 2021
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03353207
Start Date
October 30 2017
End Date
February 8 2021
Last Update
February 24 2021
Active Locations (1)
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1
Shatin Hospital
Shatin, Hong Kong