Status:
COMPLETED
Pilot Study: Postoperative Pain Reduction by Pre Emptive N-Acetylcysteine
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Maxima Medical Center
Conditions:
Postoperative Pain
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Despite current available analgesic drugs, post-surgical pain management remains challenging. A potential new target for analgesic drugs are group-II metabotropic glutamate receptors subtypes (mGlu2 a...
Detailed Description
Currently approximately 240 million surgical procedures are done worldwide on a yearly basis. lnguinal hernia repair is one of the most performed surgeries in ambulatory setting. Despite currently ava...
Eligibility Criteria
Inclusion
- Subjects scheduled for laparoscopic unilateral inguinal hernia repair
- ASA 1 or2.
- Age \>18 years.
Exclusion
- Pregnancy or lactating
- Allergy to NAC
- History of chronic pain
- Use of opioids or neuropathic analgesics
- Use of NAC prior to trial (\< 1 month of planned surgery)
- Alcoholism
- Diabetes Mellitus (insulin therapy)
- Asthma or Chronic Obstructive pulmonary Disease
- Known renal function disorders (MDRD \<ô0)
- Known liver failure (bilirubin \>1.Sx upper limit of normal)
- No written lC by patient
Key Trial Info
Start Date :
October 20 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 29 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03354572
Start Date
October 20 2017
End Date
October 29 2018
Last Update
August 13 2019
Active Locations (1)
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1
Maxima Medical Centre
Eindhoven, North Brabant, Netherlands, 5631BM