Status:
COMPLETED
Oxygen Extraction and Delivery in Elderly During Major Surgery
Lead Sponsor:
Karolinska Institutet
Conditions:
Impaired Oxygen Delivery
Surgery
Eligibility:
All Genders
65+ years
Brief Summary
This clinical observational study investigates perioperative oxygen consumption and delivery in elderly patients undergoing major surgery. The primary objectives are to characterise the perioperative ...
Detailed Description
Background Intra- and postoperative fluid therapy aims to achieve or maintain pre-specified thresholds of oxygen delivery/blood flow which can be accomplished by use of fluids with or without inotropi...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Men and women aged ≥65 years
- Major/complex surgery (BUPA AXA classification of surgical severity)
- Central and arterial venous catheterization for hemodynamic monitoring.
- Written informed consent
- Available research team for the measurements If two subjects are eligible the elder one will be chosen. If there are two subjects eligible of different gender and almost the same age, the subject with a gender that is underrepresented by two or more will be chosen. This is consistent with the purpose of including subjects with as high age as possible without interfering with recruitment.
- Exclusion Criteria
- Concomitant medication with Lithium (interferes with calibration of the LiDCO monitor)
- Weight≤ 40 kg.
- Not possible to establish arterial or central venous line.
- Planned postoperative care at high-dependency unit (POP/IMA) \<12hrs.
Exclusion
Key Trial Info
Start Date :
November 27 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 4 2018
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03355118
Start Date
November 27 2017
End Date
April 4 2018
Last Update
June 30 2022
Active Locations (1)
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1
Karolinska University hospital Huddinge
Stockholm, Sweden, 141 86