Status:
UNKNOWN
Leukocyte- and Platelet Rich Fibrin (L-PRF) Application in Impacted Mandibular Third Molar Removal Surgery
Lead Sponsor:
Lithuanian University of Health Sciences
Conditions:
Pain
Edema
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The purpose of this study was to evaluate the influence of leukocyte- and platelet-rich fibrin (L-PRF) on impacted mandibular third molar (IMTM) extraction wound healing, patient postoperative discomf...
Detailed Description
The study was designed as a prospective split-mouth clinical trial on patients who needed bilateral paired IMTM extractions. The study was conducted at the Maxillofacial Surgery Department of the Lith...
Eligibility Criteria
Inclusion
- Male and female patients with an age of 18 to 60 years;
- Healthy patients (American Society of Anesthesiologists Physical Status (ASA PS) index ≤ 2);
- Sole bilateral extractions of IMTMs during the same surgery;
- Complete root formation of tooth No. 38 and 48 at radiological examination;
- Absence of acute inflammation and/or infection in the IMTMs area;
- No history of nonsteroidal anti-inflammatory drug (NSAID) use in the past 4 weeks prior to surgery;
- Same-difficulty bilateral IMTM extractions, according to both Pederson and Juodzbalys \& Daugela classifications;
- Signed informed consent.
Exclusion
- Smoking patients;
- IMTM surgery duration difference greater than 10 minutes for each side, seeking to avoid bias;
- Different surgical manipulations taken at each IMTM surgery site;
- Presence of any neoplastic lesion (benign or malignant), clinically or radiologically evaluable, at the site or close to the impacted tooth;
- Presence of any radiolucent lesion \>1 cm at impacted tooth level;
- Absence of the adjacent tooth;
- Systemic conditions or pharmacological treatments altering oral microbiota or immunologic response;
- Alcohol or drug abuse;
- Pregnant or breastfeeding women;
- Lack of compliance by the patient or any other evidence suggesting that the patient was not likely to follow the study protocol.
Key Trial Info
Start Date :
March 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2018
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03357484
Start Date
March 1 2017
End Date
May 1 2018
Last Update
November 30 2017
Active Locations (1)
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1
Lithuanian University of Health Sciences
Kaunas, Lithuania, 50009