Status:
UNKNOWN
Patient-derived Xenograft (PDX) Modeling to Test Drug Response for High-grade Osteosarcoma
Lead Sponsor:
Peking University People's Hospital
Conditions:
Osteosarcoma
Eligibility:
All Genders
18-75 years
Brief Summary
By obtaining clinical specimens from participants with high-grade bone and soft tissue sarcomas to establish and profile as freshly implanted tumors in mice, the aim of this study is to identify agent...
Detailed Description
Patient-derived xenografts (PDX) are increasingly used as tools for drug development in pre-clinical settings, and have been shown to recapitulate the histology and behavior of the cancers from which ...
Eligibility Criteria
Inclusion
- Age \>18 years;
- Diagnosis confirmed histologically and reviewed centrally;
- Prior treatment (completed \>4 weeks before trial entry) consisted of standard high-grade osteosarcoma chemotherapy agents including doxorubicin, cisplatin, high-dose methotrexate, and ifosfamide; metastatic relapsed and unresectable progressive disease (PD);
- Eastern Cooperative Oncology Group performance status 0-1 with a life expectancy \>3 months;
- Adequate renal, hepatic, and hemopoietic function;
- Normal or controlled blood pressure;
- Surgery and/or radiotherapy completion at least 1 month before enrollment.
Exclusion
- Central nervous system metastasis;
- Have had other kinds of malignant tumors at the same time;
- Cardiac insufficiency or arrhythmia;
- Uncontrolled complications, such as diabetes mellitus and so on;
- Coagulation disorders;
- Urine protein≥ ++;
- Pleural or peritoneal effusion that needs to be handled by surgical treatment;
- Combined with other infections or wounds.
Key Trial Info
Start Date :
February 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03358628
Start Date
February 1 2018
End Date
January 31 2025
Last Update
November 30 2017
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