Status:
COMPLETED
Characterization of the Intestinal Microbiota in Patients With Inflammatory Bowel Disease and/or Spondyloarthritis and Study of the Impact of an Anti-TNF Alpha Therapy
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Spondyloarthritis
Crohn Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Spondyloarthritis and inflammatory bowel diseases are common diseases, frequently met together in overlap syndromes. Their physiopathology remains puzzling. A strong role of gut microbiota has been re...
Detailed Description
The investigators propose to conduct an exploratory study, on 10 spondyloarthritis and 20 inflammatory bowel diseases patients (10 Crohn's disease and 10 ulcerative colitis (UC), in which a first anti...
Eligibility Criteria
Inclusion
- Patients aged over 18 years
- Patients with the following conditions :
- Ulcerative colitis (UC) fulfilling the ECCO criteria
- Crohn's disease (CD) fulfilling the ECCO criteria
- Axial or peripheral spondyloarthritis (SpA) fulfilling the Assessment of SpondyloArthritis (ASAS) criteria
- Patients naïve to anti-TNF alpha, justifying the initiation of an anti-TNF alpha treatment according to current guidelines (ECCO Inflammatory bowel disease (IBD) recommendations, the recommendations of the French Society of Rheumatology for SpA)
- Patients agreeing to sign the informed consent
Exclusion
- Patient with an inflammatory disease other than UC, CD or SpA
- History of bowel resection or digestive stoma
- Taking antibiotics in the three months preceding the stool collection
- Patients with contraindication to treatment
- Pregnancy or breast feeding
Key Trial Info
Start Date :
June 5 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 16 2021
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT03359642
Start Date
June 5 2018
End Date
September 16 2021
Last Update
May 26 2022
Active Locations (1)
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1
CHU de Bordeaux - service d'Hépato-gastroentérologie
Pessac, France