Status:
UNKNOWN
What is the Best Sperm Source and Way of Sperm Selection in Cases With Abnormal sORP Levels on the Day of ICSI?
Lead Sponsor:
Ganin Fertility Center
Collaborating Sponsors:
The Cleveland Clinic
University of the Western Cape
Conditions:
Oxidative Stress
Eligibility:
MALE
18-60 years
Phase:
NA
Brief Summary
Does the level of statistic oxidation reduction potential (sORP) affects the choice of sperm source or sperm selection method used during ICSI.
Detailed Description
Reactive oxygen species (ROS) are an integral component of sperm developmental physiology, capacitation, and function. Elevated ROS levels, from processes such as infection or inflammation, can be ass...
Eligibility Criteria
Inclusion
- Diagnosed of abnormal male semen parameters such as abnormal sperm parameters according to WHO 2010 or high DNA fragmentation using TUNEL as a cause of couple infertility.
- Abnormal sORP level on the day of ICSI.
- Males with mild OTA (oligoteratoasthenozoospermia).
- Female aged 18-35 years.
- Normo responder ( \> 8 mature oocytes)
- Male will have to refrain from ejaculation no less than 1 day but no greater than 3 days prior semen specimen production on day of oocyte retrieval
Exclusion
- Normal Semen fluid analysis ( WHO 2010) during the initial assessment of the male
- Normal sORP levelat the day of ICSI
- Leukocytospermia
- Presence of varicocele.
- Known genetic abnormality
- Use of sperm donation or cryopreserved sperm
- Use of Oocyte donation
- Use of gestational carrier
- Presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previously known uterine infection
- Any contradictions to undergoing in vitro fertilization or gonadotropin stimulation
Key Trial Info
Start Date :
November 20 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2019
Estimated Enrollment :
820 Patients enrolled
Trial Details
Trial ID
NCT03360526
Start Date
November 20 2017
End Date
December 30 2019
Last Update
January 23 2019
Active Locations (1)
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1
Ganin Fertility center
Maadi, Cairo Governorate, Egypt, 12345