Status:
COMPLETED
Neuroimaging of Anesthetic Modulation of Human Consciousness
Lead Sponsor:
University of Michigan
Conditions:
Healthy
Eligibility:
All Genders
18-40 years
Phase:
PHASE4
Brief Summary
This study's purpose is to see if mental functions take place during different levels of anesthesia, using a commonly used drug (Propofol). fMRI (functional Magnetic Resonance Imaging, or "brain imagi...
Detailed Description
Administering anesthetic drugs to suppress consciousness is an imperatively important step in major surgical operations. Yet the neurobiological mechanisms that underlie loss of consciousness under ge...
Eligibility Criteria
Inclusion
- Must have a body mass index (BMI) less than 30.
- Must be right handed
- Must be English speaking
- Must be capable of giving written informed consent.
- Must have history of playing tennis (or any type of racquet sport) at least 30 times over lifetime.
Exclusion
- History of obstructive sleep apnea;
- History of a difficult airway with a previous anesthetic;
- History of neurological disorders;
- Hypertension or other cardiovascular abnormalities;
- Pulmonary hypertension or other pulmonary abnormalities;
- Gastroesophageal reflux disease (GERD) or heartburn;
- History of significant head injury with loss of consciousness;
- Learning disability or other developmental disorder;
- Allergic reactions to eggs;
- Pregnant or nursing mothers;
- Contraindications to neuroimaging methods;
- Inability or unwilling to fast, or withhold food and liquid intake, for 8 hours prior to your scheduled study visit.
- Unwilling to abstain from alcohol use for 24 hours prior to your scheduled study visit.
- History of drug use, or have a positive drug screen.
- Tattoos on the head or neck region - all other tattoos are subject to determination by investigators.
- Any impairment, activity or situation that in the judgment of the study coordinator or Principal Investigators would prevent satisfactory completion of the study protocol.
Key Trial Info
Start Date :
April 12 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 12 2019
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03361605
Start Date
April 12 2017
End Date
July 12 2019
Last Update
August 18 2020
Active Locations (1)
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1
Michigan Medicine - University of Michigan
Ann Arbor, Michigan, United States, 48109