Status:
COMPLETED
Conversion of in Vitro Fertilization Cycles to Intrauterine Inseminations in Patients With a Poor Ovarian Response to Stimulation
Lead Sponsor:
University Hospital, Angers
Conditions:
Infertility
Eligibility:
FEMALE
18-43 years
Phase:
NA
Brief Summary
The purpose of this study is to compare the efficiency of conversion to IUI and IVF in patients with a poor ovarian response to stimulation
Detailed Description
In 5 to 10% of in vitro fertilization (IVF) cycles, a poor response to ovarian stimulation (defined as less than 4 mature follicles) is noted, even though high doses of exogenous gonadotropins are use...
Eligibility Criteria
Inclusion
- Patients who accepted being included and signed the consent forms.
- Age ≥18 years et \<43 years.
- IVF cycle with and without Intra Cytoplasmic Sperm Injection (ICSI):
- "Conventional" Agonist (long and short) or antagonist protocol, using urinary or recombinant gonadotropins.
- Having only 2, 3 or 4 mature follicles (≥14 mm) on ovulation trigger day.
Exclusion
- Confirmed bilateral tubal occlusion
- Non-French speaking patients
- Partners with severe oligoasthenoteratospermia (OATS) (\<5 millions motile spermatozoa in the ejaculate)
- Suboptimal stimulation protocols:
- Protocols ≤ 150 IU of daily gonadotropins
- Mild stimulation protocols
- Natural and modified natural cycle protocols
- Women under legal guardianship
- Women with no health or social security coverage
- Women participating in other interventional trials
Key Trial Info
Start Date :
January 10 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 14 2024
Estimated Enrollment :
462 Patients enrolled
Trial Details
Trial ID
NCT03362489
Start Date
January 10 2018
End Date
March 14 2024
Last Update
June 18 2024
Active Locations (32)
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1
Victor Pauchet Clinic
Amiens, France
2
UH Angers
Angers, France, 49000
3
UH Besançon
Besançon, France
4
Jean Verdier Hospital, APHP
Bondy, France