Status:
COMPLETED
Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression and Myelodysplastic Syndromes
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Myelodysplastic Syndromes
Chronic Myelomonocytic Leukemia
Eligibility:
All Genders
50+ years
Brief Summary
Myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal bone marrow neoplasms that predominate in the elderly, with a median age at diagnosis of 70 years. MDS are characterized by p...
Detailed Description
The primary objective of MPO-MDS-pilot study is to estimate the accuracy of flow cytometric analysis of neutrophil myeloperoxidase expression in peripheral blood for the diagnosis of myelodysplastic s...
Eligibility Criteria
Inclusion
- Age ≥50 years;
- Clinical suspicion of myelodysplastic syndromes (MDS) and / or chronic myelomonocytic leukemia (CMML);
- Peripheral blood cytopenia defined by hemoglobin concentration \<10 g/dL, platelet count \<100 x109/L, and/or absolute neutrophil count \<1.8 x109/L.
Exclusion
- History of or active documented MDS or CMML;
- Admission to the intensive care unit;
- Suspicion of hematological disease other than MDS requiring bone marrow aspirate and/or biopsy (i.e., acute leukemia,…);
- Absolute neutrophil count \<0.5 x109/L;
- Not affiliated with a social security system;
- Homelessness;
- Incarcerated;
- Inability to understand research information and/or to provide non-opposition, because of language restriction, dementia, or altered mental status;
- Refusal to participate;
- Previous enrollment in the study.
Key Trial Info
Start Date :
February 22 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 6 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03363399
Start Date
February 22 2018
End Date
September 6 2018
Last Update
September 25 2018
Active Locations (2)
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1
Centre Hospitalier Universitaire Estaing
Clermont-Ferrand, France, 63003
2
Centre Hospitalier Universitaire Grenoble Alpes
Grenoble, France, 38043