Status:
COMPLETED
MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough
Lead Sponsor:
Medical University of Warsaw
Conditions:
Cough
Cough Variant Asthma
Eligibility:
All Genders
18-75 years
Brief Summary
The aim of the study is to assess the prevalence of bronchial hyperresponsiveness (BHR) in non-smoking adults with chronic cough and the prevalence of BHR in patients with upper airway cough syndrome ...
Detailed Description
The present study has the following objectives: 1. to assess the prevalence of BHR in non-smoking adults with a chronic cough, 2. to assess the prevalence of BHR in patients with UACS and GERD, 3. to...
Eligibility Criteria
Inclusion
- Adults patients aged between 18 and 75;
- Chronic cough lasting more than 8 weeks;
- Non-smoking (min. 6 months);
- Not treated with angiotensin-converting enzyme (ACE) inhibitors;
- Not treated with:
- inhaled corticosteroids or systemic corticosteroids min. 4 weeks before enrolment,
- proton pump inhibitors min. 2 weeks before enrolment,
- antihistaminic drugs 1 week before enrolment;
- With normal chest radiograph or with insignificant changes in cough pathogenesis
- Without airway infection in previous 6 weeks.
- Patients enrolled with informed consent.
Exclusion
- Patients under 18 years old and above 75 years old;
- Smokers (actual or ex-smokers shorter than 6 weeks);
- Therapy with corticosteroids (inhaled or systemic) for last 4 weeks, proton pump inhibitors for 2 weeks, antihistaminic drug for 1 week before enrolment;
- Airway infection 6 weeks preceding enrolment or during study - re-attempt to enroll after 6 weeks
Key Trial Info
Start Date :
December 31 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2020
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT03363698
Start Date
December 31 2020
End Date
December 31 2020
Last Update
June 11 2021
Active Locations (1)
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1
Department of Internal Medicine, Lung Diseases and Allergy Medical University of Warsaw
Warsaw, Masovian Voivodeship, Poland, 02-097