Status:

UNKNOWN

Hippocampus-sparing WBRT and Simultaneous Integrated Boost for Multiple Brain Metastases From NSCLC

Lead Sponsor:

Samsung Medical Center

Collaborating Sponsors:

Korean Radiation Oncology Group

Conditions:

Brain Metastases

Eligibility:

All Genders

55+ years

Phase:

PHASE2

Brief Summary

This study evaluates hippocampus-sparing whole-brain radiotherapy with simultaneous integrated boost for patients with multiple brain metastases from non-small cell lung cancer. The primary endpoint i...

Eligibility Criteria

Inclusion

  • Pathologically proven diagnosis of primary non-small cell lung cancer
  • 3 or more measurable brain metastasis ≥3 mm outside a 5-mm margin around either hippocampus on gadolinium contrast enhanced MRI within 14 days prior to registration
  • KPS ≥70
  • Age ≥55 years
  • Informed consent prior to study entry

Exclusion

  • Patients with leptomeningeal metastases
  • ≥3 organ sites of extracranial metastases (including lung-to-lung metastases) within 3 months
  • Contraindication to MRI such as implanted metal devices or foreign bodies
  • Prior radiation therapy (including SRS) to the brain

Key Trial Info

Start Date :

December 11 2017

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 1 2019

Estimated Enrollment :

80 Patients enrolled

Trial Details

Trial ID

NCT03366376

Start Date

December 11 2017

End Date

December 1 2019

Last Update

December 8 2017

Active Locations (1)

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1

Samsung Medical Center

Seoul, South Korea, 06351