Status:
COMPLETED
Efficacy and Tolerability of IRL790 in Parkinson's Disease Dyskinesia
Lead Sponsor:
Integrative Research Laboratories AB
Collaborating Sponsors:
The Clinical Trial Company
Conditions:
Parkinson Disease
Eligibility:
All Genders
18-79 years
Phase:
PHASE2
Brief Summary
Mesdopetam (IRL790) is an experimental small molecule compound with psychomotor stabilizing properties. The primary target is the dopamine D3 receptor, a target implicated in the generation of levodop...
Detailed Description
METHODOLOGY: This is a multicentre study where 74 patients with Parkinson's disease exhibiting levodopa induced dyskinesia will be randomised to receive study drug or placebo. Thirty seven patients w...
Eligibility Criteria
Inclusion
- Male or female ≥18 and ≤79 years of age.
- Signed a current Ethics Committee approved informed consent form.
- Parkinson's disease, per UK Parkinson's Disease Society (UKPDS) Brain Bank Clinical Diagnostic Criteria.
- Waking day dyskinesia of ≥25% determined as a score of ≥2 as per Question 4.1 of the MDS-UPDRS.
- On a stable regimen of antiparkinson medications for at least 30 days prior to screening, including a levodopa preparation administered not less than three times daily and willing to continue the same doses and regimens during study participation. Rescue medication such as Madopar dispersable and Apomorphine injections are allowed.
- Taking a maximum of eight regular levodopa intakes per day, excluding bedtime and night time levodopa.
- Any other current and allowed prescription/non-prescription medications and/or nutritional supplements taken regularly must have been at a stable dose and regimen for at least 30 days prior to screening and the patient must be willing to continue the same doses and regimens during study participation (this criterion does not apply to medications that are being taken pre-study only on an as-needed basis).
- Patient must be willing and able to avoid direct exposure to sunlight from day 1 to day 28.
- Able to complete at least one valid 24-hour patient diary at Visit 1.
Exclusion
- History of neurosurgical intervention related to Parkinson's disease (e.g. deep brain stimulation).
- Treatment with pump delivered antiparkinsonian therapy (i.e. subcutaneous apomorphine or levodopa/carbidopa intestinal infusion).
- History of seizures within two years prior to screening.
- History of stroke or transient ischemic attack (TIA) within two years prior to screening.
- History of cancer within five years prior to screening, with the following exceptions: adequately treated non-melanomatous skin cancers, localised bladder cancer, non-metastatic prostate cancer or in situ cervical cancer.
- Presence of cognitive impairment, as evidenced by a Mini-Mental Status Examination (MMSE) score of less than 24 during screening.
- A Hoehn and Yahr score of five when "off" as per Question 3.18 of the MDS-UPDRS, assessed during screening.
- Any history of a significant heart condition or cardiac arrhythmias within the past 5 years, any repolarisation deficits or any other clinically significant abnormal ECG as judged by the Investigator
- Severe or ongoing unstable medical condition including a history of poorly controlled diabetes; obesity associated with metabolic syndrome; uncontrolled hypertension; cerebrovascular disease, or any form of clinically significant cardiac disease; clinically significant symptomatic orthostatic hypotension; clinically significant hepatic disease, renal failure or abnormal renal function.
- Any history of a neurological other than Parkinson's disease or a psychiatric disorder, including history of DSM IV diagnosed major depression or psychosis. Patients with illusions or hallucinations with no loss of insight will be eligible. Patients with mild depression who are well controlled on a stable dose of an antidepressant medication for at least 4 weeks before screening will be eligible.
- Enrolment in any other clinical study involving medication, medical devices or surgical procedures, current or within three months prior to screening visit, or previous participation in the present study. Patients enrolled in non-interventional clinical trials will be eligible.
- Drug and/or alcohol abuse.
- History of severe drug allergy or hypersensitivity.
- If female, is pregnant or lactating, or has a positive pregnancy test result pre-dose.
- Patients unwilling to use two forms of contraception 90 days for men and 30 days for women after last IMP dose
- Any planned major surgery within the duration of the study.
- Any other condition or symptoms preventing the patient from entering the study, according to the Investigator's judgement.
Key Trial Info
Start Date :
April 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 12 2019
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT03368170
Start Date
April 12 2018
End Date
June 12 2019
Last Update
March 31 2022
Active Locations (20)
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1
Sahlgrenska University hospital
Gothenburg, Sweden
2
University hospital
Linköping, Sweden
3
University hospital
Lund, Sweden
4
Karolinska University hospital
Stockholm, Sweden