Status:
UNKNOWN
: Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
Lead Sponsor:
Louisiana State University Health Sciences Center in New Orleans
Conditions:
Local Anesthetic Drug Adverse Reaction
Local Infiltration
Eligibility:
All Genders
18-30 years
Phase:
PHASE4
Brief Summary
Anesthetics with vasoconstrictors decrease pulpal blood flow but the impact of intranasal local anesthetics on blood flow is unknown. This blinded, randomized crossover clinical trial will compare the...
Detailed Description
Informed Consent Prior to screening, informed consent will be obtained from subjects by study personnel. All questions pertaining to the study will be addressed and answered prior to the participants'...
Eligibility Criteria
Inclusion
- ASA 1 or 2 with no contraindications to the medications in this study
- no restorations on the anterior teeth, no sign of history of dental trauma, and a normal periodontium to be included
Exclusion
- known hypersensitivity to tetracaine, benzyl alcohol ester local anesthetics, p-aminobenzoic acid (PABA), oxymetazoline, lidocaine, and mepivacaine -inadequately controlled hypertension or thyroid disease, frequent nose bleeds, or history of methemoglobinemia will not be eligible. Patients taking monoamine oxidase inhibitors are not eligible as well. Pregnant women will not be eligible as a precaution.
- Subjects will be excluded if they have restorations, traumatic occlusion, orthodontic appliance, pathologic discoloration of dentition, fixed retainer on maxillary anterior, resorption, pulp canal obliteration, previous endodontic therapy, history of trauma to maxillary anterior dentition, or a fractured tooth structure
Key Trial Info
Start Date :
January 3 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2018
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT03368391
Start Date
January 3 2018
End Date
June 30 2018
Last Update
December 11 2017
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