Status:
COMPLETED
Melatonin as an Adjunctive Therapy for Chronic Periodontitis.
Lead Sponsor:
Mansoura University
Conditions:
Periodontal Diseases
Eligibility:
All Genders
35-60 years
Phase:
PHASE4
Brief Summary
Background: Melatonin is an endogenous indoleamine synthesized mainly by pineal gland and showed anti-inflammatory and antioxidant properties. Moreover, melatonin promotes osteoblastic differentiatio...
Detailed Description
INTRODUCTION Chronic periodontitis is a local chronic inflammation of the tooth supporting apparatus initiated by specific microorganisms including Porphyromonas gingivalis, Tannerella forsythia, and...
Eligibility Criteria
Inclusion
- Patients were considered eligible for participation if they had Athens Insomnia Scale (AIS) score ≥ 6.
- Each selected patient should have at least 20 teeth.
- The enrolled patients were diagnosed to have moderate to severe gCP based on Armitage's classification.
Exclusion
- diabetes mellitus.
- smokers.
- individuals having night work shifts.
- cancer patients.
- patients with autoimmune diseases or osteoporosis.
- users of antibiotics or non-steroidal anti-inflammatory drugs within the last 3 months.
- patients who were subjected to any periodontal therapy during the last year.
Key Trial Info
Start Date :
July 4 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 7 2017
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT03368430
Start Date
July 4 2016
End Date
September 7 2017
Last Update
December 11 2017
Active Locations (1)
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1
Faculty of Dentistry
Al Mansurah, Dakahlia Governorate, Egypt