Status:
COMPLETED
Effect of D-amphetamine on Reward Functioning
Lead Sponsor:
The University of Texas Health Science Center, Houston
Collaborating Sponsors:
Emory University
Conditions:
Anhedonia
Eligibility:
All Genders
18-35 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to establish the dose-response curve for therapeutic doses of d-amphetamine on tasks of motivation and reward learning in the same participants and to use d-amphetamine as...
Eligibility Criteria
Inclusion
- \- Healthy individuals
Exclusion
- Individuals with a body mass index (BMI) \<19 or \>26, as this alters dosing requirements
- Individuals with high blood pressure, abnormal Electrocardiography (EKG), any medical condition requiring regular medication (except birth control), any other regular use of a drug or supplement with potentially hazardous interactions with d-amphetamine (e.g. St. John's wort), or any other medical contraindication to amphetamine administration as determined by our study physician
- Individuals who report no prior experience with recreational drugs of any kind (including alcohol), or who report a previous adverse reaction to amphetamine
- Individuals with a current Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V) Axis I diagnosis, excluding mild Substance Use Disorders (≤ 3 symptoms)
- Individuals with a lifetime history of moderate to severe Substance Use Disorder (≥ 4 symptoms), mania or psychosis.
- Women who are pregnant.
- individuals smoking more than 10 cigarettes per week will also be excluded, to avoid confounding the effects of nicotine withdrawal with the effects of the study drugs/procedures, as participants will not be allowed to smoke during the sessions.
- individuals with less than a high-school level of education or fluency in English will be excluded as our questionnaires require high-school level fluency in English, and have not been translated and validated in other languages.
Key Trial Info
Start Date :
January 24 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 23 2019
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT03369015
Start Date
January 24 2018
End Date
May 23 2019
Last Update
November 5 2020
Active Locations (1)
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1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030