Status:
COMPLETED
High-fat Overfeeding, Hepatokines and Appetite Regulation
Lead Sponsor:
Loughborough University
Collaborating Sponsors:
Nottingham Trent University
Nottingham University Hospitals NHS Trust
Conditions:
Insulin Resistance
Type2 Diabetes Mellitus
Eligibility:
MALE
18-40 years
Phase:
NA
Brief Summary
The present study will investigate the effect of high-fat overfeeding on a group of liver-secreted proteins linked to worsened blood sugar control, as well as proteins involved in appetite control. Pa...
Detailed Description
In recent years, researchers have identified a number of liver-secreted proteins, termed "hepatokines", which are thought to play an important role in inter-organ crosstalk between the liver and other...
Eligibility Criteria
Inclusion
- Recreationally active - ≤ 2 structured exercise sessions per week
- BMI between 18.5 - 27.9 kg/m2
- Body fat percentage \< 20%
- Metabolically healthy - No known cardiovascular or metabolic disease such as diabetes, respiratory or heart disease.
- Non-smoker
- Weight stable in the past 6 months
- Normal fasting blood glucose levels (3.6 - 5.5 mmol/l)
Exclusion
- Contraindications to exercise
- Needle Phobia
Key Trial Info
Start Date :
December 11 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2018
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03369145
Start Date
December 11 2017
End Date
July 31 2018
Last Update
February 18 2019
Active Locations (2)
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1
National Centre for Sport and Exercise Medicine, Loughborough University
Loughborough, Leicestershire, United Kingdom, LE11 3TU
2
Clifton Campus, Nottingham Trent University
Nottingham, Nottinghamshire, United Kingdom, NG1 4FQ