Status:
COMPLETED
A Clinical Trail Of An Adjuvanted Inactivated H7N9 Influenza Vaccine
Lead Sponsor:
Shanghai Institute Of Biological Products
Collaborating Sponsors:
Henan Center for Disease Control and Prevention
Conditions:
H7N9 Influenza
Eligibility:
All Genders
12+ years
Phase:
PHASE1
PHASE2
Brief Summary
The aim of this study is to investigate the immunogenicity and safety of the inactivated whole-virion vaccine for teenagers and adults. The investigators will test the vaccine in participants aged 12...
Eligibility Criteria
Inclusion
- Over the age of 12 years,healthy population
- Subjects/ (and the guardian) informed consent, voluntarily participated and signed the informed consent form, with the ability to use thermometers, scales and to fill in diary cards as required
- To comply with the requirements of clinical trial program, receive blood test before and after immunization and cooperate with follow-up
Exclusion
- A history of influenza A (H7N9) virus infection or suspected infection Abnormal blood routine, blood biochemistry and urine routine examination indexes
- Allergy to any component in the vaccine (allergy history of any previous vaccination), especially for egg allergy
- History of asthma, history of thyroid resection, vascular nerve edema, diabetes mellitus, hypertension can not be controlled by medicine, liver and kidney diseases or malignant tumor history
- Suffered from any serious illness, such as cancer, autoimmune disease, progressive atherosclerotic disease or complications of diabetes, chronic obstructive pulmonary disease, need oxygen therapy for acute or progressive liver or kidney disease, congestive heart-failure etc.
- History of signs disease or symptoms of neurological symptoms
- Suffering from severe chronic diseases (such as Down's syndrome, diabetes, sicklemia or neurological disorders, Green's Barre syndrome)
- Acute attacks of various acute or chronic diseases in the past 7 days
- Known or suspected of respiratory disease, acute infection or chronic disease active period, HIV infection, cardiovascular disease, severe hypertension, malignant tumor during treatment, skin diseases
- Congenital malformations or developmental disorders, genetic defects, severe malnutrition etc
- No spleen, functional absence of spleen, and splenectomy or splenectomy without any condition
- Autoimmune diseases or immunodeficiency have been treated with immunosuppressive agents in the past 6 months
- History of epilepsy, convulsions, or a family history of psychosis
- Abnormal coagulation function (such as coagulation factor deficiency, coagulation disorders, platelet abnormalities), or obvious bruising or coagulopathy
- The blood products were received within 3 months prior to the acceptance of the vaccine
- Received a live vaccine within 14 days prior to receiving the vaccine, or received a subunit or inactivated vaccine within 7 days
- Fever within 3 days prior to vaccination, axillary temperature ≥38 ℃
- Being febrile When inoculating vaccine, axillary temperature \>37.0 ℃
- Women are pregnant or in the near future planned pregnancy or pregnancy test positive
- Participants in another clinical trial
Key Trial Info
Start Date :
December 29 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 15 2019
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT03369808
Start Date
December 29 2017
End Date
November 15 2019
Last Update
October 15 2024
Active Locations (1)
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1
Suiping Center for Disease Control and Prevention
Zhumadian, Henan, China, 463100