Status:
COMPLETED
Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD
Lead Sponsor:
XuanwuH 2
Conditions:
Subjective Cognitive Decline
Preclinical Alzheimer's Disease
Eligibility:
All Genders
60-80 years
Brief Summary
This study is affiliated to Sino Longitudinal Study on Cognitive Decline, SILCODE. To establish models of normal and pathological cognitive aging.To collect the longitudinal data of SCD population, to...
Detailed Description
This study is affiliated to Sino Longitudinal Study on Cognitive Decline, SILCODE. Alzheimer's disease (AD) is the most common cause of dementia, which severely injures multiple domains of cognitive f...
Eligibility Criteria
Inclusion
- 1\. NC
- Older than 60, right handedness, Han nationality;
- Have no cognitive decline complains, with neither worry nor concern about their cognition;
- Scores of standardized neuropsychological tests scale adjusted for age, sex and education are in normal range;
- Physical examination is negative;
- Review medical history and family history is negative, accessory examination don't show disease could cause cognitive decline;
- Could cooperate collection of multi-modal magnetic resonance imaging, once a year, for continueously five years.
- 2\. SCD
- Presence of self-perceived continuous cognitive decline compared to previous normal status and unrelated to an acute event;
- Failure to meet the following criteria for MCI.
- SCD-plus
- Presence of self-perceived continuous cognitive decline compared to previous normal status and unrelated to an acute event;
- Concerns (worries) associated with memory complaint;
- Failure to meet the following criteria for MCI.
- 3\. MCI
- Clinical Dementia Rating (CDR) score of 0.5 as well as failure to meet the criteria for dementia
- Having impaired scores (defined as \>1 SD below the age-corrected normative mean) on both measures within at least one cognitive domain (i.e., memory, language, or speed/executive function);
- Having impaired scores in each of the three cognitive domains sampled;
- the Functional Activities Questionnaire (FAQ) ≥9.
- 4\. AD Inclusion Criteria The diagnosis of AD syndrome is based on the diagnostic guidelines for dementia due to AD delivered by the National Institute on Aging-Alzheimer's Association workgroups (NIA-AA)with a total CDR score of 1.
Exclusion
- Claustrophobia, with metals in the body that cannot be examined by MRI, including metal dentures or other contraindications for examination;
- Left handedness or ambidextrality.
Key Trial Info
Start Date :
March 15 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT03370744
Start Date
March 15 2017
End Date
December 31 2022
Last Update
September 8 2023
Active Locations (1)
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1
Department of Neurolgy,Xuanwu Hospital of Capital Medical University
Beijing, Beijing Municipality, China, 100053