Status:
COMPLETED
DNA Methylation Profile of the SOCS-1 Gene Promoter in Smokers Patients With Chronic Periodontitis.
Lead Sponsor:
University of Sao Paulo
Conditions:
Periodontal Diseases
Epigenetics
Eligibility:
All Genders
30+ years
Brief Summary
Periodontitis is related to host genetics, constitution of the dental biofilm and environmental factors such as smoking. DNA methylation is a mechanism of genetic expression that can inhibit or silenc...
Detailed Description
This was an experimental type study with parallel controls, comparing two groups, a group with consumption of 10 minimum cigarettes per day, with a diagnosis of chronic periodontitis. And another cont...
Eligibility Criteria
Inclusion
- Chronic Periodontitis carriers - presence of proximal insertion loss ≥5 mm in more than 30% of the teeth present.
- Periodontal pocket ≥ 5mm
- Smokers who have smoked 10 or more cigarettes per day for the past five years.
- No positive history of basic periodontal treatment in the last six months.
Exclusion
- Extensive prosthetic involvement.
- Using anti-inflammatories.
- Pregnant or nursing.
- Presence of systemic alterations that compromise host response or require prophylactic medication for treatment.
- History of constant use of oral antiseptics in the last six months.
Key Trial Info
Start Date :
June 6 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 18 2017
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03371446
Start Date
June 6 2016
End Date
November 18 2017
Last Update
December 13 2017
Active Locations (1)
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1
Arthur Belem Novaes Junior
Ribeirão Preto, São Paulo, Brazil, 14040-904