Status:
COMPLETED
Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Respiration, Artificial
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of this study is to study the combined impact of mechanical ventilation and sepsis on the human diaphragm in order to establish the neutral, protective or destructive character of mechanical v...
Eligibility Criteria
Inclusion
- Patient at least 18 years of age, male or female requiring abdominal or thoracic surgery or multi-organ sampling;
- Affiliated to a social security or similar system;
- Not subject to legal protection;
- Having given consent to participate in the study (or consent from the trusted person)
- Control group (C): non-septic mesocolic programmed abdominal or thoracic surgery: gastrectomy, esophagectomy, pancreatectomy, hepatectomy
- Sepsis group (S): Abdominal or thoracic surgery in a septic context (peritonitis, mediastinitis, pleural abscess)
- Group Mechanical Ventilation (MV): Patient in brain death for which a multi organ sample is planned
- Mechanical Ventilation + Sepsis (S-MV) group: Patient under controlled mechanical ventilation to undergo abdominal or thoracic surgery in a septic context (peritonitis, mediastinitis, pleural abscess)
Exclusion
- Pregnant woman (diagnosis of interrogation)
- severe and / or unbalanced chronic respiratory disease; severe malnutrition
- Long-term corticosteroids\> 5mg / day for more than 1 month
- Myopathy
- surgery by laparoscopic
- By group:
- Control group: Sepsis, preoperative controlled mechanical ventilation and preoperative hemodynamic instability
- Mechanical Ventilation Group: Sepsis, duration of controlled mechanical ventilation \<24 hours or\> 7 days
- Sepsis Group: Preoperatively controlled mechanical ventilation
- Mechanical Ventilation - Sepsis Group: duration of controlled mechanical ventilation \<24 hours or\> 7 days
Key Trial Info
Start Date :
June 16 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 17 2021
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT03371602
Start Date
June 16 2017
End Date
July 17 2021
Last Update
July 7 2023
Active Locations (1)
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1
Croix Rousse Hospital
Lyon, France, 69004