Status:
WITHDRAWN
Radiomics-based Surrogate of Endoscopy (rEndosc) (CHESS1703)
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Collaborating Sponsors:
Beijing YouAn Hospital
Beijing 302 Hospital
Conditions:
Esophageal Varices in Cirrhosis of the Liver
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Esophageal varices (EVs) resulting from portal hypertension are a prevalent complication of cirrhosis with a high mortality when variceal hemorrhage (VH) occurs. Screening endoscopy for EVs is recomme...
Detailed Description
Esophageal varices (EVs) resulting from portal hypertension are a prevalent complication of cirrhosis with a high mortality when variceal hemorrhage (VH) occurs. Screening endoscopy for EVs is recomme...
Eligibility Criteria
Inclusion
- 18-75 years;
- HBsAg positive;
- confirmed cirrhosis based on results of histologic examination of liver tissue or combined physical, laboratory, and radiologic findings, including a nodular surface, a coarse texture, and an enlarged caudate lobe of the liver on ultrasonography, CT, or MR imaging.
Exclusion
- active alcohol abuse (less than 6 months of alcohol abstinence); portal thrombosis;
- history of treatments for portal hypertension (drug therapy, such as β-blocker, vasopressin) within 2 weeks;
- prior surgeries (such as splenectomy, partial splenic embolization/devascularization, transjugular intrahepatic portosystemic shunt);
- prior endoscopic therapies (such as endoscopic variceal ligation);
- previous variceal hemorrhage;
- acute-on-chronic (sub-acute) liver failure;
- malignant tumor (such as hepatocellular carcinoma);
- cirrhotic portal hypertension with isolated gastric varices or ectopic varices;
- inability to adhere to study procedures (such as heart failure, renal failure);
- pregnancy or unknown pregnancy status;
- no informed consent.
Key Trial Info
Start Date :
December 18 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 18 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03373123
Start Date
December 18 2017
End Date
December 18 2018
Last Update
June 19 2019
Active Locations (9)
Enter a location and click search to find clinical trials sorted by distance.
1
302 Hospital of PLA
Beijing, Beijing Municipality, China
2
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, China
3
Beijing YouAn Hospital, Capital Medical University
Beijing, Beijing Municipality, China
4
Chinese PLA General Hospital
Beijing, Beijing Municipality, China