Status:
COMPLETED
Impact of Chlordecone on Active Chronic Hepatitis
Lead Sponsor:
Centre Hospitalier Universitaire de la Guadeloupe
Conditions:
Fibrosis, Liver
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Chlordecone is known to induce liver damage in rat and mice but no data exists in human being. However chlordecone was used until 1993 in French West Indies for banana fields, it is important to test ...
Detailed Description
Actually, there is no data concerning the impact of chlordecone on the evolution of fibrosis to cirrhosis in chronic hepatitis whereas many studies have been reported liver damage in mice. The goal of...
Eligibility Criteria
Inclusion
- Age above 18 years
- Active chronic hepatitis B or C or alcoholic
- Patient without previous antiviral therapy, activity confirmed by histology or elevated transaminases
- Alcohol consumption more than 20g/d for women and 30g/d for men responsible of chronic alcoholic disease
- Seronegative HIV status, inform consent signed, health insurance
Exclusion
- Inactive chronic hepatitis
- Other chronic hepatitis as auto-immune hepatitis, hemochromatosis, wilson disease, acute hepatitis due to medication, transplantation, antiviral or imunosupressive treatment, psychiatric disease
- Co-infection with HIV, HBV or HCV
- Pregnancy
Key Trial Info
Start Date :
November 8 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 21 2015
Estimated Enrollment :
283 Patients enrolled
Trial Details
Trial ID
NCT03373396
Start Date
November 8 2011
End Date
December 21 2015
Last Update
December 14 2017
Active Locations (1)
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1
Hospital University Center of Pointe-à-Pitre
Pointe-à-Pitre, Guadeloupe, 97159