Status:
UNKNOWN
Effect of Dietary Salt Reduction on Blood Pressure in Kidney Transplant Recipients
Lead Sponsor:
Epsom and St Helier University Hospitals NHS Trust
Conditions:
Blood Pressure
Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cardiovascular morbidity and mortality is increased in kidney transplant patients. High blood pressure (BP) contributes significantly to this risk and is also associated with shortened allograft survi...
Detailed Description
Our hypothesis is that lower salt intake will reduce BP in patients with a kidney transplant. We propose that this will translate into better CV and renal protection via reductions in proteinuria, end...
Eligibility Criteria
Inclusion
- Patients who have received a kidney transplant ≥ 6 months previously who have a BP \>130 mm Hg systolic and/or \>80 mm Hg diastolic, or are receiving treatment for hypertension.
Exclusion
- BP \< 120/80 on blood pressure treatment
- BP \>160/100
- Variation in Creatinine \>20% over preceding 2 months
- Secondary hypertension due to a cause other than CKD
- Heart failure (LVEF \<30% or NYHA class II - IV)
- Myocardial Infarction within 6 months
- Stroke within 6 months
- Current diagnosis of cancer
- Liver disease
- Bilateral arterio-venous fistulae
- Evidence of significant active infection
- Females who are pregnant or breastfeeding
- Hyponatremia (Na \<130mmol/L) or Hypernatremia (Na \>150mmol/L)
- Histologically confirmed episode of rejection within 6 months
- Steroids dose change in preceding 2 months
- Patients who are not able to give full informed consent
- Initial 24hr urinary sodium \<80mmol/24hrs
Key Trial Info
Start Date :
October 11 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2019
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT03373500
Start Date
October 11 2017
End Date
June 1 2019
Last Update
February 8 2019
Active Locations (1)
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1
Epsom and St Helier University Hospitals NHS Trust
Carshalton, Surrey, United Kingdom, SM5 1AA