Status:
UNKNOWN
Evaluation Effect of Crocina on The Cellular Immune Responses in Osteoarthritis Patients
Lead Sponsor:
Mashhad University of Medical Sciences
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
40-75 years
Phase:
PHASE3
Brief Summary
The effect of Crocina on the production of IL-4, IL-1 bet, IL-17, IL-10 and TGF-beta: The effect of crocina on gene expression of transcription factors T-bet, GATA-3. FOXP3, ROR-γt,; The effect of hel...
Detailed Description
The effect of crocina on the production of IL-4, IL-1β, IL-17, IL-10 and TGF-β by ELISA assay;The effect of crocina on gene expression of transcription factors T-bet, GATA3, FOXP3, ROR-γt by Real-Time...
Eligibility Criteria
Inclusion
- Osteoarthritis patients must have
- Aged 40 to 75.
- The severity of joint damage between grade 2 and grade 3 based on radiographic images.
- No history of joint surgery.
- No history of injury.
- No diabetic disorders.
- No rheumatism.
- No kidney disease.
- No osteonecrosis and gout.
- No long history of anti-inflammatory drugs consumption.
- No insufferable jobs;
- The Body Mass Index (BMI) of 30 or less.
Exclusion
- Osteoarthritis patients should not have:
- Aged less than 40 and more than 75
- With the severity of joint damage of the in grade 1 and grade 4 based on radiographic images.
- With history of joint surgery.
- With history of injury
- With diabetic disorders, rheumatism, kidney disease, osteonecrosis and gout.
- With long history of anti-inflammatory drugs consumption.
- Having insufferable jobs.
- With a BMI of 30 or more.
Key Trial Info
Start Date :
July 20 2016
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 30 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03375814
Start Date
July 20 2016
End Date
July 30 2018
Last Update
December 18 2017
Active Locations (1)
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1
Jaleh Shariati sarabi
Mashhad, Razavi Khorasan Province, Iran